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In a large bowl, combine the cornmeal, flour, garlic powder, and cayenne together.
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Pour the buttermilk into a separate bowl and season with salt and pepper.
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Dip the tomatoes in the buttermilk and then dredge them in the cornmeal mixture, coating both sides well.
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Place a large cast iron skillet over medium heat and coat with the oil.
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When the oil is hot, pan-fry the tomatoes (in batches if necessary) until golden brown and crispy on both sides, about 3 to 4 minutes on each side.
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Carefully remove the tomatoes and drain on paper towels.