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For the roast: Combine the seasonings and rub the mixture over the roast. Place in the slow cooker, cover and cook on low for 8-10 hours.
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Remove the meat and let it rest for 15 minutes.
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Cut diagonally across the grain into thin slices.
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Serve with horseradish sauce.
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While the roast is cooking, prepare the horseradish sauce by combining all ingredients. Cover and chill.