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In a large skillet over medium heat, brown the ground beef and onion.
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Stir in the flour, granulated bouillon, salt, pepper, and garlic and onion powders (and cayenne, if using).
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Saute all together until flour is absorbed, about 5 minutes.
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Gradually stir in the Worcestershire sauce and milk.
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Bring it all to a simmer, stirring, and cook until thickened, about 5 to 10 minutes.
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Serve over toast, biscuits, noodles, rice, or potatoes.